![]() Quoting: MayeulCThat's a bit off-topic, sorry about that. Last edited by MayeulC on 6 November 2018 at 11:16 pm UTC ![]() Speaking of the GoL system info, looks like Whitewolfe80 needs to update his :D I also agree on your stance, and it seems that more and more people ( Stardock interactive?) in the game industry think the same. I might wait until I hit framerate issues in GPU-bound games, which hasn't been the case already, I'm just sharing the tip. Silicon lottery and all The complicated part would be getting this to run on Linux the good part is my card is a Sapphire with a bios switch, so I don't risk bricking it. ![]() BTW, I'm very tempted to have a look at a bios editor available on some forums, that lets you enable extra compute units on your Fury if they are not damaged, and turn it into a Fury X. Worth it, although it tends to run very hot (~80☌, mostly). Hi! :D Best bang my buck could buy doing the crypto craze. Also hi one of the other 11 people on this site with a Fury. I could go on a rant about why nvidia is bad as a company especially in a FOSS ecosystem like Linux. They really like using their own proprietary tech instead of open standards. I personally have a problem with the way nvidia does things from a business standpoint. It's a shame I can't justify buying the remastered version when I haven't finished the original (it honestly feels like I bought this game yesterday when it was just out).To be honest all devs should do Linux + AMD. Quoting: Scoopta Quoting: MayeulCWow, they actually care a lot, they might have one dev using Linux + AMD ^^. ![]() That's a bit off-topic, sorry about that. It's currently only available on Steam and I think it's well worth it, excellent game. The mouse cursor should also be hidden when using a gamepad, along with multiple other fixes. Not stopping there, the patch also includes some performance improvements so you should see less hitching and stuttering during gameplay as it will now save games asynchronously. Another Linux-specific fix, was some kind of interference from motion sensors in the PS4 controller which should no longer happen. Not any more! Klei put out a patch yesterday which should fix the problems along with a crash when shutting the game down on Linux. The trouble is, the game was practically broken for AMD GPU users. I wasn't honestly expecting it to be improved as much as it has. Released back in October, Mark of the Ninja: Remastered bundled the DLC of the original game along with some graphical enhancements, much improved gamepad support for Linux gamers along with much better multi-monitor handling on Linux too. Two Linux-specific issues were found and fixed. In the process of passing you will get access to «cursed tattoos», which will give your characters new opportunities.Klei have been working on improving Mark of the Ninja: Remastered with a recent beta that's now live for everyone. You must be cunning, savvy and smart to outplay the enemy. The path to victory does not always lie through cruelty. The presented game will show you what it is like to be a real ninja. Passage in the style of a pacifist allows the gamer to get new achievements and open up nice bonuses. Here, in the arsenal, the protagonist has stunning blows that incapacitate the enemy for a while. In this mode, you can go through the game not only silently, but also without killing anyone. The Special Edition, in turn, expands the scope of the main plot, adds a new level, the main character, additional items, and comments from the developers to the game.Īn interesting mode in Mark of the Ninja Remastered is New Game Plus. In the new version of Mark of the Ninja, the game developers mentioned above have improved the sound, adapting it to 5.1 format systems, completely reworked the visual component, improved character models, detailed environmental textures, revived shadows, reworked cut scenes and effects. Mark of the Ninja Remastered - is a re-release of one of the best 2D action games of our time. FILE SIZE : 7.1 GB (File Compressed) If you like this game, BUY IT to support the software developers!
0 Comments
![]() As you maneuver your way through each of the 18 progressive levels, you can build up an arsenal worthy of a match against the greatest mega-boss of all time: THE DEMONSTAR. You will even test your skills over the water, where ships fire at will to take you down! To destroy each boss, you will have to search for the many weapons such as lasers, homing missiles, and many more. ![]() Then turn your attack on the ground, dodging the pursuit of enemy tanks, while wiping out the enemy's ground forces. Do you want fast-paced, reflex-jerking, edge-of-your-seat action? Demonstar is all of these and more! Get pumped from the exhilarating space scenes that challenge you with relentless kamikaze fighters, asteroids that will turn you to dust, and bosses that will send you into the next galaxy. XmediaStorm - For you to record, capture, manage, convert and share video,picturesīubble Bobble World - Remake of a popular classic game Bubble Bobble.Īlien Shooter - Be a hero - Save Humanity from the attack by evil monster aliens from outer space.The most thrilling vertical scrolling shooter on the market! Demonstar takes shooters to the extreme with Multiplayer/Network capabilities, Force Feedback joystick support, 3-D rendered graphics, explosive sound effects, and a brilliant soundtrack. StockQuoter - Manages your portfolio and downloads intraday and historical stock quotes. Secure, easy to configure and use.Įliminad - Blocks banners, popups, flash ads, messenger service ads, and detects spyware.ĭemonStar - Classic - The Xidus have been developing a powerful DemonStar baseship to destroy Earth Got password - Lightweight, feature-rich, FREE password manager. Honestech Photo DVD - Anyone can create lasting video from photos and pictures with Photo DVD. Protector Plus 2000 - Protector Plus is an anti-virus software designed for Windows. Play circular chess against computer, a friend or make it your advanced chess trainer. Featuring 3 levels of difficulty, move and time limit option, and a picture and number mode.īyzantine Circular Chess - This computer game develops human intellect with a new approach to a traditional chess game. JE Slide - An electronic version of the classic 4x4 sliding puzzle game. You can create your own levels with the use of our L!ght Deluxe Level Editor. Light Deluxe - Your main goal is to direct light-rays from lights sources to light receivers! You are provided with tools like mirrors, light filters, prisms, etc. With it, you could turn your pictures into announcements, invitations, holiday cards, and more, all by yourself. Choose from templates, and add your own pictures and text. Photo Card Maker - An easy to use software to create your photo cards in a minute. All new graphics, particle engine, shapes and textures. We have 7 different style arcade games, each one unique and special. Includes new Virtual Deck with over 40 card games. Green Moon - Prepare to go on a fantastic journey which will take you from damp prehistoric forests, to the sultry deserts of ancient Egypt, to dirty Wild West saloons, and luxurious medieval castles!Īrcade Convoy Revelation - Unique take on classic games including an all new way to play Tetris. The gameplay is like in Memory the popular card game for kids.Ĭhicken Invaders 3 Easter - Dash across the galaxy to save Earth from the latest & greatest chicken threat! It is possible to transfer created puzzles as usual files. Enter IP address of the computer that creates/hosts the game. Mosaicers - Creation and solving of puzzles (mosaics) created on the basis of any picture. 3) Select a Connection Type ( TCP/IP is used for internet play ). Do you want fast-paced, reflex-jerking, edge-of-your-seat action? DemonStar is all of these and more! To destroy each boss, you will have to search for the many weapons such as lasers, homing missiles,Īpproved before they are publicly visible.ĭemonStar - Classic Related Titles: Dins Curse - A single player and co-op multiplayer action RPG with 141 class combinations, infinite number of dynamically generated towns, real consequences, and a dynamic, evolving world. Download DemonStar - Classic (Latest Version: 4.01)ĭemonStar - Classic - The Xidus have been developing a powerful DemonStar baseship to destroy EarthThe most thrilling vertical scrolling shooter on the market! DemonStar takes shooters to the extreme with Multiplayer/Network capabilities, Force Feedback joystick support, 3-D rendered graphics, explosive sound effects, and a brilliant soundtrack. Kliegman MD, in Nelson Textbook of Pediatrics, 2020 462.5 Long QT Syndromes Two studies-one on HEK cells and mathematical modeling and one in neuronal cells derived from a patient with TS by iPSC technology-showed that roscovitine, a cyclin-dependent kinase inhibitor that increases inactivation of the L-type channel, can revert the electrophysiologic abnormalities. Studies of IPS-derived cells suggested a possible novel therapeutic approach to the disease. 28 Gene expression analysis showed an upregulation of the CaMKII gene in neuronal precursor cells from the patient with TS, supporting the role of CaMKII in the pathogenesis of TS. The action potentials of TS neurons were approximately 37% wider at the midpoint than those of controls, which is consistent with a loss of channel inactivation. 27 A subsequent study assessed the biophysical abnormalities observed in iPSC-derived TS neurons. ![]() Electrophysiologic recording and calcium imaging studies performed in iPSC-derived myocytes revealed irregular contraction (which could explain cardiac hypertrophy of some patients), excess Ca 2+ influx and prolonged action potentials. Timothy syndrome pathophysiology was studied in induced pluripotent stem cells (iPSCs) obtained from skin biopsy specimens from patients and differentiated into cardiac myocytes. Priori, in Cardiac Electrophysiology: From Cell to Bedside (Sixth Edition), 2014 Timothy Syndrome–Induced Pluripotent Stem Cells All three pedigrees hosting R518C/H– CACNA1C presented with this unique and atypical phenotypic sequela consistent with cardiac-only Timothy syndrome (COTS). Patch-clamp studies on both R518C and R518H revealed a complex Ca v1.2 electrophysiologic phenotype consisting of loss of current density and inactivation in combination with increased window and late current. A subsequent CACNA1C exon 12–specific analysis in five additional unrelated index cases with a similar phenotype of LQTS and a personal or family history of HCM identified two additional pedigrees with mutations at the same amino acid position, either R518C or R518H. None of the patients had extracardiac phenotypes, such as those observed with TS. In 2015, Boczek and colleagues 32 used whole-exome sequencing to identify a novel CACNA1C mutation R518C that was most likely responsible for the observed phenotype in a large pedigree with concomitant LQTS, hypertrophic cardiomyopathy (HCM), congenital heart defects, and SCD. Zipes MD, in Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2019 Cardiac-Only Timothy Syndrome Involuntary eye movements: Uncontrolled and rapid eye movements (nystagmus) may also accompany the syndrome.Douglas P.Seizures: People with this condition are more prone to develop seizures.Abnormalities in the spine: Along with other deformities in the vertebrae, scoliosis-a lateral curvature of the spine-as well as kyphosis, or hunchback, can also accompany the condition.Cleft tongue: In approximately five to 30 percent of cases, those affected will have cleft tongue, in which the tip is split.Frequent infection: People with the syndrome are at elevated risk for bacterial infection. ![]() Photosensitivity: In many cases, the skin of those affected is extra-sensitive to sunlight.Claw hand, an atypical curvature of fingers, has also been reported. In addition, the position of the thumb may also be atypical in that it’s closer to the wrist. Altered hand anatomy: Those with the condition may have extra small fingers and toes.Heart defects: Heart defects associated with Smith Lemli Opitz syndrome include the development of a hole in the wall between the two upper chambers ( atrial septal defect), or one between lower chambers ( ventricular septal defect).Autism: Also known as autism spectrum disorder (ASD), this condition leads to impaired social skills, speech, and nonverbal communication abilities as well as repetitive behaviors.Attention deficit hyperactivity disorder (ADHD): This developmental disorder is characterized by difficulty regulating behavior and impulses as well as hyperactivity.Males are more likely to experience this, with an under-developed penis and undescended testes. Ambiguous genitals: The genitals of those affected may be less defined. ![]() Dental development abnormalities: Early eruption of adult teeth and enlarged gums are signs of Smith Lemli Opitz syndrome. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |